Nucleofill Medium, Strong, Eyes or Soft — which variant suits you?

What is Nucleofill, and why four variants?

Nucleofill belongs to a group of biostimulators based on polynucleotides (PDRN/PN) — long DNA chains typically derived from salmon or trout. Polynucleotides are natural carriers of biological information. They act on fibroblasts, stimulating collagen and hyaluronic acid production, regenerate cells, and improve microcirculation and hydration. The result isn't "added volume" — that's what classic fillers do. Instead, it's an improvement in skin quality from within — density, elasticity, radiance and a reduction in fine lines.

Why four variants? Because skin in different facial zones has a different structure and different needs. The delicate skin under the eyes is a completely different material to the skin on the cheek. And skin on someone in their forties responds to stimulation differently than skin belonging to someone just starting out with prevention. The manufacturer of Nucleofill created four formulas to allow precise work — matched to a specific zone and a specific level of need.

Four variants — four tasks

Below is an overview of the four Nucleofill variants and their indication profiles. This isn't a "better/worse" ranking — it's a map of tools, from which your doctor selects what's right for your skin.

How to recognise what your skin needs — a home test

Before you go for a consultation, it's worth taking a moment to observe your own skin closely. The questions below don't replace a doctor's assessment, but they help you walk into the conversation with specifics, rather than a vague "I'd like to do something about this":

• What does your skin look like in the morning, before skincare? Grey, dull, no radiance, a "tight" feeling? That signals a lack of hydration and reduced density → direction: Medium or Soft.
• Do you see a clear loss of facial contour, sagging cheeks or deeper wrinkles? Skin that has "slipped" downward → direction: Strong.
• Is the issue dark circles, fine lines around the eyes, or a generally "tired" eye area? This zone calls for precision → direction: Eyes.
• Is your skin sensitive, prone to redness, or reactive to new ingredients? Start with a gentler approach → direction: Soft as a first step.
• How old are you, and how would you assess your skin's general rate of ageing? In your twenties: prevention (Soft/Medium). In your forties with visible changes: Medium or Strong, depending on your specialist's assessment.

It's worth remembering that Nucleofill variants aren't mutually exclusive. Doctors often combine, for instance, Eyes for the eye area with Medium for the rest of the face in a single session. This isn't about extravagance — it's about precision. Different facial zones have different needs, and it helps when the treatment reflects that.

When to combine Nucleofill with other methods

Nucleofill rarely works best in complete isolation. Polynucleotides make an excellent foundation for regenerative therapy — but skin usually needs other steps too, especially when the changes are multidimensional. Typical, effective combinations include: