A treatment room at J'adoreAESTHETIC MEDICINE
Tired, grey, "lifeless" skin — thin and dehydrated, skin that stays dull despite good home care — is the most common reason people ask about polynucleotides. This is not a filler and not "a stronger moisturiser". Polynucleotides (PDRN) are next-generation regenerative biostimulators. Once injected into the skin, they trigger its own renewal: they prompt cells to produce collagen, hydrate intensely from within, and protect against oxidative stress.
They don't change your features — they improve skin quality. At J'adore Instytut, the treatment is performed by a doctor or experienced cosmetologist (depending on the preparation and protocol). Below you'll find everything worth knowing before your first visit — including how the preparations differ and where the price differences come from.
series of 3–4 sessions every 2–3 weeks + maintenance
How it works
Polynucleotides (marked as PDRN or PN) are long chains of genetic material fragments — usually derived from fish (including salmon or trout roe) and purified into a safe, fully biocompatible form. Once injected into the skin, they don't "fill" it — they trigger regeneration at cellular level.
They work in several ways at once: they stimulate fibroblasts (the cells that produce collagen and elastin) into action, bind water and hydrate from within, act as an antioxidant and anti-inflammatory (protecting skin from oxidative stress), and improve microcirculation. The result is skin that's denser, firmer, better hydrated and more radiant — naturally, without changing your features.
The most common myth to bust: "polynucleotides are just stronger hydration". They're not — they're primarily about regeneration and rebuilding skin quality; hydration is one of the effects, not the main goal.
AESTHETIC MEDICINE
Polynucleotides are injected intradermally — shallow, in a series of micro-deposits — not deep beneath the tissue, like a dense contour-building preparation. The gel doesn't take the place of lost volume, and it doesn't provide any mechanical support: it spreads through the dermis in a fine network, exactly where fibroblasts and capillaries do their work. A doctor decides during consultation — after taking a history and assessing the tissue — at what depth and in what quantity the preparation is administered, and whether it's indicated at all in your case. This is a medical qualification, not a choice from a treatment menu.
The mechanism itself has two stages, spread over time. First comes the physical effect: long polynucleotide chains bind water and form a hydrated gel in the skin, which immediately improves hydration and tissue elasticity — this is more pronounced in variants with added hyaluronic acid, since hyaluronic acid also retains water strongly. Then comes the biological part: as the chains gradually break down, the fragments act as a signal to fibroblasts to resume producing collagen and elastin — which is exactly why the effect builds over weeks rather than appearing overnight. The preparation doesn't stay in the skin indefinitely: it absorbs naturally, broken down by tissue enzymes, so the result is temporary by design and most people need maintenance sessions.
Good to know: polynucleotides are essentially fragments of DNA — which is exactly why fish-derived material comes into play at all. A DNA molecule is built from the same four bases in fish and in humans, so tissue reads the purified chains as biocompatible rather than as a foreign body. This is also why the fish allergy question comes up at every consultation, not just "as a precaution".
Ideal for
Treatment areas: face, eye area, neck, décolletage, hands. A specialist chooses the preparation variant and series plan after assessing your skin.
For her and for him
Most often, this is work on radiance, firmness and complexion regeneration — restoring freshness, and supporting thin, tired, dehydrated skin and the delicate eye area. This is classic polynucleotides for women — often part of a "skin quality" plan alongside fillers or Botox.
The areas we support
For men, this is mainly about repairing skin stressed by sun, oxidative stress, daily shaving, and usually a lack of routine SPF protection. This is polynucleotides for men — the goal is discreet: denser, healthier, better-hydrated, less tired skin, with no visible "change".
The areas we support
Good to know: the same mechanism — prompting the skin to repair itself — means polynucleotides are also sometimes used to support healing after barrier-disrupting treatments (laser, peels). Aesthetic radiance is just one face of the same regeneration.
Safety
With polynucleotides, the result and its safety depend on a few things worth asking about at any salon:
Polynucleotides are administered by an aesthetic medicine doctor or an experienced cosmetologist — depending on the preparation and protocol. This is an injectable treatment, so technique, hygiene and proper qualification based on a medical history all matter.
Polynucleotides are a technologically advanced category — efficacy and safety depend on the purity and origin of the material. We work exclusively with preparations from authorised distributors.
Since PDRN is derived from fish material, we always ask at consultation about allergies to fish and seafood, as well as medications and conditions that could affect the treatment.
Red flag: suspiciously cheap polynucleotides · A bargain price is the most common warning sign — with an injectable preparation, origin and storage matter as much as technique. You have every right to ask about the preparation's name and variant, its distributor, and who performs the treatment. A good salon will answer without hesitation.
AESTHETIC MEDICINE · Polynucleotides
Contraindications
Some contraindications are permanent (or need individual assessment), and some are temporary — in that case, we simply postpone the treatment until the situation resolves.
From the specialist's chair
The two things most often overlooked: fish allergy and cold sores. With PDRN, the material is fish-derived, so an allergy needs to be stated clearly. And a cold sore "just on the lip" still matters for a facial treatment — an active virus is a risk regardless of location. Better to postpone by a few days.
This isn't a complete list — we'll go through your medications, health conditions and previous treatments individually at consultation (and refer you to a doctor if there's any medical doubt).
What to expect
The key point: this is a cumulative treatment. Hydration and a "fresher" look can be noticeable almost immediately, but the real regenerative effect builds gradually — the full result comes from the series, not a single visit.
Some people say "it's probably not working" after one session. That's completely normal — polynucleotides build their effect over a series. That's why we set out a plan for 3–4 sessions upfront and don't judge the result after the first visit.
The result usually lasts from six months to a year, and each session in the series reinforces the last. After that, single maintenance sessions every several months to about a year are enough.
Portfolio
A record of the work in our salons — the place where we publish treatment frames and, after photo sessions, results.
A record of results — in preparation. We publish photographs of our clients only with their consent.
Polynucleotides and your lifestyle
The first few days are about protecting skin that's still recovering. There's really one rule — in the first 24 hours, avoid irritating the injection sites or provoking bruising, and pay particular attention to sun protection during the first week.
Skip makeup over the treated area for roughly 24 hours — give your skin and the injection sites time to settle calmly.
High temperatures and chlorinated water irritate the skin and can worsen swelling. It's best to wait 2–3 days before sauna, hammam or pool.
Sharply increased circulation encourages bruising and swelling. Light activity is fine, but hold off on intense training for 2–3 days.
Avoid sunbathing and sunbeds, and SPF 50+ is essential during the first week — skin that's still regenerating is more sensitive to UV.
Hold off on strong acids and retinol until the series is complete, or as advised — keep your skincare gentle during this time.
Alcohol dilates blood vessels and increases the risk of bruising — best avoided on the day of the treatment.
Before the treatment, gentle skincare is all you need; it's worth stopping strong acids a few days beforehand and — in agreement with your specialist — anything that increases bleeding risk.
Polynucleotides
Price list
Eye area
30 min · Lumi Eyes
Area, number of sessions and salon — we'll work out the price straight away.
Warsaw, Żelazna 59 · 799 zł
Prefer to call? Żelazna 573 569 431 · Mińska 732 228 806 · Karmelicka 732 228 846
Gift voucher
Buy a voucher for this treatment in the J'ADORE online boutique — an elegant gift, redeemable at the salon of your choice.
Voucher pricePLN 699
Buy the voucher (opens in a new tab)Purchase and payment take place in the J'ADORE online store. The voucher is valid for 12 months from purchase and covers the selected treatment variant.
See also
AESTHETIC MEDICINENucleofillSee treatment: Nucleofill
AESTHETIC MEDICINEProfhiloSee treatment: Profhilo
AESTHETIC MEDICINEBiostimulators / skin boostersSee treatment: Biostimulators / skin boosters
AESTHETIC MEDICINEInjectable collagenSee treatment: Injectable collagen
AESTHETIC MEDICINEEye area mesotherapySee treatment: Eye area mesotherapy
AESTHETIC MEDICINENeedle mesotherapySee treatment: Needle mesotherapy
AESTHETIC MEDICINEPRP plasmaSee treatment: PRP plasmaThe result lastsapprox. 6–12 months after the seriesJ’adore Instytut
Medical information. Polynucleotides (PDRN) are injectable regenerative preparations; this treatment is medical in nature. The text above is for informational purposes only and does not constitute advertising or medical advice. Indications, choice of preparation and variant, and contraindications are determined by a specialist during an individual consultation (and, where medical doubt exists, referred to a doctor).